Key Roles of Renal Aquaporins in Water Balance and Water-Balance Disorders.

نویسندگان

  • Søren Nielsen
  • Tae-Hwan Kwon
  • Jørgen Frøkiaer
  • Mark A. Knepper
چکیده

The discovery of aquaporins by Agre and co-workers provided an answer to the long-standing biophysical question of how water can pass cell membranes. The identification and characterization of several aquaporins expressed in the kidney has allowed detailed insight, at the molecular level, into the fundamental physiology and pathophysiology of renal water metabolism.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Physiology and pathophysiology of renal aquaporins.

The discovery of aquaporin-1 (AQP1) by Agre and associates answered the longstanding biophysical question of how water specifically crosses biological membranes. In the kidney at least 7 aquaporins are expressed at distinct sites. AQP1 is extremely abundant in the proximal tubule and descending thin limb and is essential for urinary concentration. AQP2 is exclusively expressed in the principal ...

متن کامل

Aquaporins in the kidney: from molecules to medicine.

The discovery of aquaporin-1 (AQP1) answered the long-standing biophysical question of how water specifically crosses biological membranes. In the kidney, at least seven aquaporins are expressed at distinct sites. AQP1 is extremely abundant in the proximal tubule and descending thin limb and is essential for urinary concentration. AQP2 is exclusively expressed in the principal cells of the conn...

متن کامل

AFLUID Mar. 45/3

Marples, David, Jørgen Frøkiaer, and Søren Nielsen. Long-term regulation of aquaporins in the kidney. Am. J. Physiol. 276 (Renal Physiol. 45): F331–F339, 1999.—The discovery of the aquaporin family of water channels has greatly improved our understanding of how water crosses epithelial cells, particularly in the kidney. The study of the mechanisms involved in the regulation of collecting duct w...

متن کامل

Long-term regulation of aquaporins in the kidney.

The discovery of the aquaporin family of water channels has greatly improved our understanding of how water crosses epithelial cells, particularly in the kidney. The study of the mechanisms involved in the regulation of collecting duct water permeability, in particular, has advanced very rapidly since the identification and characterization of aquaporin-2 (AQP2) in 1993. One of the more surpris...

متن کامل

The Role of Aquaporins in the Kidney of Euryhaline Teleosts

WATER BALANCE IN TELEOST FISH IS MAINTAINED WITH CONTRIBUTIONS FROM THE MAJOR OSMOREGULATORY ORGANS: intestine, gills, and kidney. Overall water fluxes have been studied in all of these organs but not until recently has it become possible to approach the mechanisms of water transport at the molecular level. This mini-review addresses the role of the kidney in osmoregulation with special emphasi...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society

دوره 15  شماره 

صفحات  -

تاریخ انتشار 2000